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All Of Us Arrays module⚓︎

WorkFlow Launcher (WFL) implements aou-arrays module to support secure and efficient processing of the AllOfUs Arrays samples. This page documents the design principles and assumptions of the module as well as summarizes the general process of module development.

aou-arrays module implements arrays workload as a continuous workload, which means all samples are coming in like a continuous stream, and WFL does not make any assumption of how many samples will be in the workload or how to group the samples together: it hands off the workload creation and starting process to its caller.

API⚓︎

aou-arrays module, like others, implements the following multimethod dispatchers:

  • start-workload!
  • add-workload!

It supports the following API endpoints:

Verb Endpoint Description
GET /api/v1/workload List all workloads, optionally filtering by uuid or project
GET /api/v1/workload/{uuid}/workflows List all workflows for a specified workload uuid
POST /api/v1/create Create a new workload
POST /api/v1/start Start a workload
POST /api/v1/stop Stop a running workload
POST /api/v1/exec Create and start (execute) a workload
POST /api/v1/append_to_aou Append one or more sample(s) to an existing AOU workload, unless stopped

Different from the fixed workload types that caller only needs to create a workload with a series of sample inputs and then simply start the workload, aou-arrays module requires the caller to manage the life cycle of a workload on their own in a multi-stage manner:

  1. The caller needs to create a workload and specify the type to be AllOfUsArrays, the caller will receive the information of the created workload if everything goes well, one of which is the uuid of the workload.
  2. Once the workload information is being reviewed, the caller needs to "start" the newly created workload to tell WFL that "this workload is ready to accept incoming samples". Without this "start" signal WFL will refuse to append any sample to this workload.
  3. The caller can append new individual samples to an existing started workload, and these new samples will be analyzed, processed and submitted to Cromwell as long as it has valid information.

To give more information, here are some example inputs to the above endpoints:

GET /api/v1/workload

shell curl 'http://localhost:8080/api/v1/workload' \ -H 'Authorization: Bearer '$(gcloud auth print-access-token) \ -H 'Accept: application/json'

GET /api/v1/workload?uuid={uuid}

shell curl 'http://localhost:8080/api/v1/workload?uuid=00000000-0000-0000-0000-000000000000' \ -H 'Authorization: Bearer '$(gcloud auth print-access-token) \ -H 'Accept: application/json'

GET /api/v1/workload?project={project}

shell curl 'http://localhost:8080/api/v1/workload?project=(Test)%20WFL%20Local%20Testing' \ -H 'Authorization: Bearer '$(gcloud auth print-access-token) \ -H 'Accept: application/json'

Note

project and uuid are optional path parameters to the /api/v1/workload endpoint, hitting this endpoint without them will return all workloads. However, they cannot be specified together.

GET /api/v1/workload/{uuid}/workflows

shell curl 'http://localhost:8080/api/v1/workload/00000000-0000-0000-0000-000000000000/workflows' \ -H 'Authorization: Bearer '$(gcloud auth print-access-token)

POST /api/v1/create

shell curl -X POST 'http://localhost:8080/api/v1/create' \ -H 'Authorization: Bearer '$(gcloud auth print-access-token) \ -H 'Accept: application/json' \ -H 'Content-Type: application/json' \ -d '{ "executor": "https://cromwell-gotc-auth.gotc-dev.broadinstitute.org", "output": "gs://broad-gotc-dev-wfl-ptc-test-outputs/aou-test-output/", "project": "Example Project", "pipeline": "AllOfUsArrays" }'

POST /api/v1/start

shell curl -X POST 'http://localhost:8080/api/v1/start' \ -H 'Authorization: Bearer '$(gcloud auth print-access-token) \ -H 'Accept: application/json' \ -H 'Content-Type: application/json' \ -d $'{ "uuid": "00000000-0000-0000-0000-000000000000" }'

POST /api/v1/stop

Stops the workload from accepting new samples. See also: /api/v1/append_to_aou.

shell curl -X POST 'http://localhost:8080/api/v1/stop' \ -H 'Authorization: Bearer '$(gcloud auth print-access-token) \ -H 'Accept: application/json' \ -H 'Content-Type: application/json' \ -d $'{ "uuid": "00000000-0000-0000-0000-000000000000" }'

POST /api/v1/workload/append_to_aou

shell curl -X POST 'http://localhost:8080/api/v1/append_to_aou' \ -H 'Authorization: Bearer '$(gcloud auth print-access-token) \ -H 'Accept: application/json' \ -H 'Content-Type: application/json' \ -d $'{ "uuid": "00000000-0000-0000-0000-000000000000", "notifications": [ { "zcall_thresholds_file": "foo", "sample_lsid": "foo", "bead_pool_manifest_file": "foo", "chip_well_barcode": "foo", "sample_alias": "foo", "green_idat_cloud_path": "foo", "red_idat_cloud_path": "foo", "cluster_file": "foo", "reported_gender": "foo", "gender_cluster_file": "foo", "params_file": "foo", "extended_chip_manifest_file": "foo", "analysis_version_number": 1 }, { "zcall_thresholds_file": "foo", "sample_lsid": "foo", "bead_pool_manifest_file": "foo", "chip_well_barcode": "foo", "sample_alias": "foo", "green_idat_cloud_path": "foo", "red_idat_cloud_path": "foo", "cluster_file": "foo", "reported_gender": "foo", "gender_cluster_file": "foo", "params_file": "foo", "extended_chip_manifest_file": "foo", "analysis_version_number": 5 } ] }'

Workload Model⚓︎

WFL designed the following workload model in order to support the above API and workload submission mechanism.

Initially, it has the following schema:

List of relations Schema | Name | Type | Owner | Size | Description --------+--------------------------------+----------+----------+------------+------------- public | databasechangelog | table | foo | 16 kB | public | databasechangeloglock | table | foo | 8192 bytes | public | workload | table | foo | 16 kB | public | workload_id_seq | sequence | foo | 8192 bytes |

the workload table looks like:

id | commit | created | creator | cromwell | finished | input | items | output | pipeline | project | release | started | uuid | version | wdl ----+--------+---------+---------+----------+----------+-------+-------+--------+----------+---------+---------+---------+------+---------+----- (0 rows)

Note that different from the fixed workload types, input, output and items are not useful to aou-arrays workload since these fields vary from sample to sample. Any information the caller provided to these fields will stored as placeholders.

More importantly, even though id is the primary key here, (pipeline, project, release) works as the unique identifier for arrays workloads, for instance, if there's already a workload with values: (AllOfUsArrays, gotc-dev, Arrays_v1.9), any further attempts to create a new workload with exact the same values will return the information of this existing workload rather than create a new row.

Once the caller successfully creates a new sample, there will be a new row added to the above workload table, and a new table will be created accordingly:

List of relations Schema | Name | Type | Owner | Size | Description --------+--------------------------------+----------+----------+------------+------------- public | allofusarrays_000000001 | table | foo | 16 kB | public | allofusarrays_000000001_id_seq | sequence | foo | 8192 bytes | public | databasechangelog | table | foo | 16 kB | public | databasechangeloglock | table | foo | 8192 bytes | public | workload | table | foo | 16 kB | public | workload_id_seq | sequence | foo | 8192 bytes |

The allofusarrays_00000000X table has the following fields:

id | analysis_version_number | chip_well_barcode | status | updated | uuid ----+-------------------------+-------------------+-----------+-------------------------------+-------------------------------------- 1 | 1 | 0000000000_R01C01 | Succeeded | 2020-07-21 00:00:00.241218-04 | 00000000-0000-0000-0000-000000000000 2 | 5 | 0000000000_R01C01 | Failed | 2020-07-21 00:00:00.028976-04 | 00000000-0000-0000-0000-000000000000 Among which (analysis_version_number, chip_well_barcode) works as the primary key, any new samples that collide with the existing primary-keys will be omitted.

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