Impact test results. The x-axis presents the negative log p-value obtained by eVIP (L1000), and the y-axis represents the negative log p-value obtained by cmVIP. The dotted lines represent the significant threshold considered in this study (0.05). Each point is one allele and its color indicates the prediction agreement between the two platforms; green is impactful by both platforms, gray is neutral by both platforms, pink is impactful by Cell Painting only, and blue is impactful by L1000 only.