Directionality Test

ABCB9

ABCB9_p.G443C ABCB9_p.R281L ABCB9_p.V140M
AKR1B1

AKR1B1_p.F252L AKR1B1_p.P14R AKR1B1_p.Q27K
AKT1

AKT1_p.D323Y AKT1_p.E17K
ARAF

ARAF_p.D429A ARAF_p.L96Q ARAF_p.S214C ARAF_p.S214C, p.D429A ARAF_p.S214F ARAF_p.S214F, p.D429A ARAF_p.V145L
ATF2

ATF2_p.A481V ATF2_p.K106R ATF2_p.P70S ATF2_p.T339A
BRAF

BRAF_p.A762E BRAF_p.D594H BRAF_p.G466A BRAF_p.G466E BRAF_p.G466V BRAF_p.G469S BRAF_p.G469V BRAF_p.H574N BRAF_p.H574Q BRAF_p.K601N BRAF_p.L485S BRAF_p.L613F BRAF_p.N581S BRAF_p.P367R BRAF_p.R682W BRAF_p.V600E BRAF_p.W450L
CASP8

CASP8_p.E147D
CCND1

CCND1_p.E172K
CGREF1

CGREF1_p.P21L CGREF1_p.Q286K CGREF1_p.Q295K
CTNNB1

CTNNB1_MAPK7 CTNNB1_p.F777S CTNNB1_p.G34V CTNNB1_p.G367V CTNNB1_p.I140T CTNNB1_p.S33N CTNNB1_p.S37C CTNNB1_p.S45F CTNNB1_p.T41A CTNNB1_p.V600G
DARC

DARC_p.T211S DARC_p.W253R
DCAF8

DCAF8_p.D570G DCAF8_p.E102Q DCAF8_p.E63K DCAF8_p.G588C DCAF8_p.P156S DCAF8_p.R559P
DOK1

DOK1_p.A127V DOK1_p.A32T DOK1_p.P419S DOK1_p.S460I DOK1_p.V393L DOK1_p.W26C
EGFR

EGFR_p.769_770insASV EGFR_p.773_774insH EGFR_p.774_775insHV EGFR_p.A237Y EGFR_p.D837A EGFR_p.E545Q EGFR_p.ELR746del EGFR_p.ELREA746del EGFR_p.ELREA746del.p.T790M EGFR_p.G901V EGFR_p.H1129Y EGFR_p.K754E EGFR_p.K754I EGFR_p.L62R EGFR_p.L833F EGFR_p.L858R EGFR_p.L861Q EGFR_p.L907M EGFR_p.Q1020H EGFR_p.R1052I EGFR_p.R222L EGFR_p.R377S EGFR_p.S645C EGFR_p.S768I EGFR_p.S921R EGFR_p.T790M EGFR_p.T790M, p.L858R.o EGFR_p.V769L
ERBB2

ERBB2_p.774_775insAYVM ERBB2_p.776_776G>VC ERBB2_p.D845A ERBB2_p.S310F ERBB2_p.S418T
FAM173B

FAM173B_p.R101L FAM173B_p.R187P
FBXW7

FBXW7_p.D101E FBXW7_p.D211N FBXW7_p.P620R FBXW7_p.V464E
FCGR3B

FCGR3B_p.A78S FCGR3B_p.A78T FCGR3B_p.D147H FCGR3B_p.K179T FCGR3B_p.L218P FCGR3B_p.L23P
FGFR3

FGFR3_p.D280G FGFR3_p.D617A FGFR3_p.R399H FGFR3_p.S779R
GPR137B

GPR137B_p.C212S GPR137B_p.L95I GPR137B_p.S231F GPR137B_p.Y135N
HAVCR2

HAVCR2_p.G86V HAVCR2_p.L127F HAVCR2_p.P115A HAVCR2_p.P6S
HRAS

HRAS_p.G13R HRAS_p.Q61L
IDH2

IDH2_p.K130del IDH2_p.R188W IDH2_p.S249G
KEAP1

KEAP1_p.A159P KEAP1_p.A191T KEAP1_p.D389Y KEAP1_p.D479G KEAP1_p.E117K KEAP1_p.E218V KEAP1_p.E611D KEAP1_p.F139L KEAP1_p.F246L KEAP1_p.F280Y KEAP1_p.G333C KEAP1_p.G333S KEAP1_p.G364C KEAP1_p.G417E KEAP1_p.G417R KEAP1_p.G419W KEAP1_p.G480W KEAP1_p.G524C KEAP1_p.G603W KEAP1_p.H96L KEAP1_p.I461V KEAP1_p.L100P KEAP1_p.L268P KEAP1_p.M110I KEAP1_p.M503K KEAP1_p.N397del KEAP1_p.P278R KEAP1_p.P278S KEAP1_p.Q284L KEAP1_p.R204P KEAP1_p.R260L KEAP1_p.R261P KEAP1_p.R272H KEAP1_p.R272P KEAP1_p.R320M KEAP1_p.R320P KEAP1_p.R415C KEAP1_p.R460G KEAP1_p.R470C KEAP1_p.R470H KEAP1_p.R470S KEAP1_p.R601W KEAP1_p.S102L KEAP1_p.S144F KEAP1_p.T142M KEAP1_p.V155A KEAP1_p.V99L KEAP1_p.W497L KEAP1_p.Y141F
KRAS

KRAS_p.D33E KRAS_p.G12A KRAS_p.G12C KRAS_p.G12D KRAS_p.G12F KRAS_p.G12R KRAS_p.G12S KRAS_p.G12V KRAS_p.G12Y KRAS_p.G13C KRAS_p.G13D KRAS_p.G13V KRAS_p.Q61L
MAP2K1

MAP2K1_p.C121S MAP2K1_p.EI102del MAP2K1_p.F53L MAP2K1_p.K57N MAP2K1_p.M146I MAP2K1_p.S331R
MAPK7

MAPK7_p.D46N MAPK7_p.L806R MAPK7_p.T28I
MAX

MAX_p.R35L MAX_p.R60del
MDM2

MDM2_p.E421Q MDM2_p.S221C
MET

MET_ex14del MET_p.E1314G MET_p.F1341L MET_p.H644N MET_p.K2N MET_p.M1160L MET_p.S441C MET_p.Y1003F MET_p.Y1235H
MYC

MYC_p.E366Q MYC_p.N215I
NFE2L2

NFE2L2_p.T80K
NRAS

NRAS_p.Q61L
PIK3CA

PIK3CA_p.123_124MP>IA PIK3CA_p.E453Q PIK3CA_p.E542K PIK3CA_p.E545K PIK3CA_p.E600K PIK3CA_p.E726K PIK3CA_p.H1047R PIK3CA_p.L699M PIK3CA_p.Q137L PIK3CA_p.Q296E PIK3CA_p.R108H
PIK3R3

PIK3R3_p.F380L PIK3R3_p.M295T PIK3R3_p.P127L PIK3R3_p.R245C PIK3R3_p.S408R
PPP2R1A

PPP2R1A_p.A541G PPP2R1A_p.C148F PPP2R1A_p.C329F PPP2R1A_p.Q372L PPP2R1A_p.R183W PPP2R1A_p.R258H PPP2R1A_p.R46S PPP2R1A_p.V229L PPP2R1A_p.W140C
PTEN

PTEN_p.H123Y PTEN_p.M35I
RAF1

RAF1_p.G14S RAF1_p.S259F
RARA

RARA_p.D256Y RARA_p.F286T RARA_p.M284I RARA_p.P20S RARA_p.P29T RARA_p.S229R
RB1

RB1_p.A772S RB1_p.E398L RB1_p.Y756C
RBM10

RBM10_p.E4K RBM10_p.G153C RBM10_p.I316F RBM10_p.Q416L RBM10_p.W658Y RBM10_p.Y580F
RBM45

RBM45_p.A8T RBM45_p.D117N RBM45_p.D434Y RBM45_p.E216K RBM45_p.M126I RBM45_p.R81S
RIT1

RIT1_p.A192T RIT1_p.A192T.unin RIT1_p.A77P RIT1_p.F82L RIT1_p.K23E RIT1_p.M90I RIT1_p.Q40L RIT1_p.R122L RIT1_p.T76insTDLT RIT1_p.TA83del
SERPINB5

SERPINB5_p.A165T SERPINB5_p.A42F SERPINB5_p.A7T SERPINB5_p.D141A SERPINB5_p.G142V SERPINB5_p.I159S SERPINB5_p.T37I
STC2

STC2_p.A188V STC2_p.D36Y STC2_p.G283R STC2_p.K163R STC2_p.M10V STC2_p.N59I STC2_p.R236S STC2_p.R5W
STK11

STK11_p.D176A STK11_p.D176H STK11_p.D194Y STK11_p.D194Y.unin.fs STK11_p.G242W STK11_p.G251F STK11_p.G251V STK11_p.G56V STK11_p.G56W STK11_p.H168R STK11_p.K78E STK11_p.L245F STK11_p.N181I STK11_p.N181Y STK11_p.P221L STK11_p.S216F STK11_p.W239C
TPK1

TPK1_p.D29Y TPK1_p.E81Q TPK1_p.G48C TPK1_p.K111M TPK1_p.L185I TPK1_p.P152T TPK1_p.T205S TPK1_p.T213S
U2AF1

U2AF1_p.S34F
ZBTB24

ZBTB24_p.G568C ZBTB24_p.G693S ZBTB24_p.K123M ZBTB24_p.M78I ZBTB24_p.Q669R
ZNF597

ZNF597_p.F16L ZNF597_p.L283V ZNF597_p.R247T ZNF597_p.V21L

Directionality Test

Directionality test results. The x-axis indicates the polarized log p-value obtained by L1000, and the same for Cell Painting in the y-axis. Each point is one allele with the inner circle colored according to the predictions obtained by each platform